Mar 01 2008
GERIATRICIAN # 1 ORLANDO MENOPAUSE and HORMONE REPLACEMENT
What is Menopause? It refers to the time when menstruation ceases completely. THe ovaries decrease their output of estrogen and progesterone and women begin experiencing the effects of suboptimal levels of these hormones. IN addition to signifying the end of a woman’s ability to have children, declines in these feamle hormones affect the entire endocrine system. This is a process that takes approximately 3 to 5 years to complete. The early phase or transitional phase is referred to as the climateric or peri-menopause. Menopause is considered complete when a woman has had no period for a full year. Although timing varies from woman to woman, menopause is generally completed by the time they reach their early 50s.
What to expect at Menopause and Beyond? Every woman is an individual, of course, but there are number of side effects that can generally be anticipated.Though some side effects may be considered temporary nuisances to be “toughed out”, the reality is that the decline of a woman’s hormonal levels results in changes that can seriously affect her physicial and mental health as well as her prospects for longevity.
The most common side effect associated with menopause are hot flashes, a sudden sensation of intense heat.Some women break out with red blotches on their chest, back or arms, some sweat profusely, some also experience cold and shivering until their bodies readjust. Hot flushes are considered to be a direct result of decreasing estrogen levels and they can linger for years.
Other changes are vaginal and urinary changes such as thin, less elasticity and more susceptibility to infections. As well as uncomfortable intercourse. Also incontinence and development of urinary tract infections. Also Loss of libido, emotional changes (emotional peaks and valleys and depression). Also osteoporosis. One out of every two post-menopausal women will suffer some degree of osteoporosis. In osteoporosis bones become fragile, thin and more prone to fracture. Also there is an association with cardiovascular disease. As a result of estrogen deficiency, LDL cholesterol increases and HDL decreases. Early recognition, lifestyle changes and hormone modulation have been shown to be very effective in reducing the incidence and severity of cardiovascular disease in post-menopausal women.. In addition to diminished levels of estrogen and progesterone, testosterone (also produced in the ovaries) and growth hormone are also reduced during menopause..
Hormone Modulation can help: Much of the medical field agrees that hormone theraphy:
- Reduces the risk of osteoporosis, reduces hot flashes, reduces the risk of cardiovascular disease, improves mood and psychological well-being, iresults in firmer body and more youthfull appearance, improves mental alertness, focus and concentration, increases energy and vitality, improves desire for sex, increases physical stamina and muscle strenght, reduces body fat.
How safe is Hormone Replacement therapy? THere has been controversy about the use of estrogen and progestin in healthy post-menopausal women. This controversy is a result of an article published in the July 17, 2002 issue of the Journal of the American Medical Association that reported on the results of the Women’s Health Initiative Trial. The results of this trial linked the ise of Premarin and progesterone to the development of health risks that, in the opinion of the authors, exceed benefits.
Many authorities believe this study was poorly designed and has many flaws. One of the major concerns is that premarin and provera, the drugs used in the study, are not bio-identical of human estrogen and progestin. Premarin, in fact, is obtained from horse urine and contains nearly three-dozen horse estrogen compounds, only three of which are found in humans. Another concern is that during the course of the study, all subjects received the same doses of hormones with no consideration given given to the adjsuting dosing on blood levels. It is reasonable to conclude that many of the subjects had hormone levels that greatly exceeded normal physiologic levels that greatly exceeded normal physiologic ranges-ranges we would consider unsafe. Finally, we could also argue that there was a sex bias in the study. A similar study of men and testosterone replacement therapy based on the administration on non-bioidentical hormones (obtained from ground-up horse testicles for example) would be quickly dismissed and viewed with great suspicion by the medical community, but the same circumstance was allowed for thousands of women in the WHI study and recommendations are now being made based on that study. We beleive bio-identical estrogen and progestin replacement therapy that is performed in a controlled clinical setting where therapeutic levels are closely monitored and dosing is adjusted accordingly will dramatically improve a woman’s quality of life. While there are still contraindications for some women ( e.g., those with history of breast disease and uterine cancer), many physicians now feel that the benefits far outweigh the risks.